Manchester United survived an early scare to beat League Two Cambridge United and set up an FA Cup fifth-round trip to Preston North End.
Striker Tom Elliott should have given Cambridge a shock lead in the replay but shot against a post after a Daley Blind error within the first minute.
Louis van Gaal’s side took the lead through Juan Mata’s close-range finish before Marcos Rojo headed in a second.
James Wilson’s 18-yard low strike sealed the win for the dominant hosts.
They will travel to Deepdale on 16 February to face League One promotion hopefuls Preston for the first time since 1972, after North End beat Sheffield United 3-1 on Tuesday.
Cambridge defied the odds to hold their Premier League opponents to a 0-0 draw at the Abbey Stadium but, with the exception of the first minute, they never looked capable of causing another upset.
