Arsenal hammered an abject Galatasaray side but could not claim top spot in Group D as Borussia Dortmund avoided defeat in their final group game.
The Gunners – criticised for defeat at Stoke on Saturday – responded with three goals inside 30 minutes, Lukas Podolski powering an opener.
Aaron Ramsey slotted a second and added a stunning left-footed 35-yard volley.
Wesley Sneijder hit a free-kick consolation before Podolski rolled a second with the final kick of the game.